Journal Title：Journal Of Medicinal Chemistry

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following:

* Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.

* Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.

*Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.

* Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.

*Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.

* Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.

* Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.

* Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

《藥物化學(xué)雜志》發(fā)表的研究有助于理解分子結(jié)構(gòu)與生物活性或作用方式之間的關(guān)系。

一些適當(dāng)?shù)奶囟I(lǐng)域包括：

* 設(shè)計(jì)、合成和生物學(xué)評(píng)估用作藥理學(xué)工具的新型生物活性化合物、診斷劑或標(biāo)記配體。

* 對(duì)已報(bào)道的系列進(jìn)行分子修飾，從而顯著提高對(duì)其結(jié)構(gòu)-活性關(guān)系 (SAR) 的理解。現(xiàn)有系列的常規(guī)擴(kuò)展，如果不采用新的化學(xué)或生物學(xué)方法，或者沒有顯著增加對(duì)系列 SAR 的基本理解，通常不會(huì)被接受出版。

*相關(guān)配體和靶標(biāo)的結(jié)構(gòu)生物學(xué)研究（X 射線、NMR 等），旨在研究生物活性化合物作用中的分子識(shí)別過(guò)程。

*大分子靶標(biāo)的分子生物學(xué)研究（例如，定點(diǎn)誘變），可提高對(duì)分子識(shí)別的理解。

*計(jì)算研究，為當(dāng)前普遍感興趣的化合物系列的 SAR 提供新的見解，或分析其他可用數(shù)據(jù)，從而促進(jìn)藥物化學(xué)知識(shí)。

*具有顯著價(jià)值的實(shí)質(zhì)上新穎的計(jì)算化學(xué)方法，可用于生物活性分子的鑒定、優(yōu)化或靶標(biāo)相互作用分析。

*分子結(jié)構(gòu)對(duì)生物活性分子的分布、藥代動(dòng)力學(xué)和代謝轉(zhuǎn)化的影響化合物。這可能包括新型前體藥物的設(shè)計(jì)、合成和評(píng)估。

* 廣泛應(yīng)用于藥物化學(xué)的新方法，但前提是這些方法已經(jīng)在相關(guān)分子上進(jìn)行了測(cè)試。

Journal Of Medicinal Chemistry創(chuàng)刊于1959年，由American Chemical Society出版商出版，收稿方向涵蓋醫(yī)學(xué) - 醫(yī)藥化學(xué)全領(lǐng)域，在行業(yè)領(lǐng)域中學(xué)術(shù)影響力很大，屬于TOP期刊，國(guó)際一流期刊，關(guān)注度和專業(yè)度非常高，所以對(duì)原創(chuàng)文章要求創(chuàng)新性很高，過(guò)審難度很高，如果您有志于TOP期刊，建議關(guān)注此刊。平均審稿速度 約2.1個(gè)月 ，影響因子指數(shù)6.8，該期刊近期沒有被列入國(guó)際期刊預(yù)警名單，廣大學(xué)者值得一試。